• It was down to them, one little lab trying its best to execute the “faster better cheaper” plan which contained within it (as they often pointed out) a contradiction of the second law of thermodynamics among other problems, a plan that they knew could only really achieve two out of the three qualities in any real-world combination, but making the attempt anyway, finding that the only true “cheaper” involved was the cost of their own labor and the quality of their own lives…

    — Kim Stanley Robinson, The Martians
  • It is the paradox of a free and tolerant society that in order for it to work, intolerance cannot be tolerated.

    — Kim Stanley Robinson, The Martians
  • Long experience has taught me this about the status of mankind with regard to matters requiring thought: the less people know and understand about them, the more positively they attempt to argue concerning them, while on the other hand to know and understand a multitude of things renders men cautious in passing judgment upon anything new.

    — Galileo Galilei
  • I have always found that there’s an inverse relationship between the number of people in a room and the amount of useful work that can be done.

    — John Scalzi, The End of All Things
  • Judgments like ‘like’ and ‘dislike’ and ‘smiles’ and ‘frowns’ were limited to junior high. Someone would write a note and it would say, ‘Do you like unicorns and stickers?’ and you’d say, ‘Yeah, I like unicorns and stickers! Smile!’ That kind of thing. But now it’s not just junior high kids who do it, it’s everyone…

    — Dave Eggers, The Circle
  • The difference between right-wing people and left-wing people. You said it all came down to imagination. Conservative people don’t usually have very much, so they find it hard to imagine what life is like for people who aren’t just like them. They can only empathise with people just like they are: the same sex, the same age, the same class, the same golf club or nation or race or whatever. Liberals can pretty much empathise with anybody else, no matter how different they are. It’s all to do with imagination; empathy and imagination are almost the same thing, and it’s why artists, creative people, are almost all liberals, left-leaning. Hard-headed people – business people – didn’t have that sort of imagination; it’s all directed at seeing business opportunities, identifying gaps in the market, spotting weaknesses in rivals.

    — Iain Banks, The Steep Approach to Garbadale
  • The great horizon for evidence-based medicine is finding new methods and tools for disseminating the evidence we already have, to doctors and other decision-makers. This will require innovative collaboration between coders, pharmacists, librarians, doctors and academics. At the simplest level, I’m always frustrated that I can’t press a button, when reading a systematic review, to say ‘notify me when this summary is updated with new trial results’. In more elaborate terms, it’s clear that we should be moving medical knowledge and trial results into structured databases; and perhaps embedding high-quality contextual advice into a doctor’s routine workflow, as they sit at the computer in their office.

    — Ben Goldacre, Bad Pharma
  • She is increasingly of the opinion that worrying about problems doesn’t help solve them, but she hasn’t really found an alternative yet. Surely you can’t just leave them there.

    — William Gibson, Pattern Recognition
  • Homo sapiens are about pattern recognition, he says. Both a gift and a trap.

    — William Gibson, Pattern Recognition
  • Artists or the military. That’s something that tends to happen with new technologies generally: the most interesting applications turn up on the battlefield, or in a gallery.

    — William Gibson, Spook Country
  • Intelligence, Hollis, is advertising turned inside out.

    — William Gibson, Spook Country
  • There were cameras literally everywhere, in London. So far, he’d managed not to think about them. He remembered Bigend saying they were a symptom of autoimmune disease, the state’s protective mechanisms ’roiding up into something actively destructive, chronic; watchful eyes, eroding the healthy function of that which they ostensibly protected.

    — William Gibson, Zero History
  • Everything about us, everything around us, everything we know and can know of is composed ultimately of patterns of nothing; that’s the bottom line, the final truth. So where we find we have any control over those patterns, why not make the most elegant ones, the most enjoyable and good ones, in our own terms?

    — Iain M. Banks, Consider Phlebas